| Date | Location | Result | |
| 02/28/22 | California, PA (Convocation Center) | California (PA) 72, Slippery Rock 55 | Box score |
| 02/26/22 | Erie, PA | Mercyhurst 80, Slippery Rock 65 | Box score |
| 02/23/22 | Slippery Rock, PA | Slippery Rock 79, Edinboro 72 | Box score |
| 02/21/22 | California, PA (Convocation Center) | Slippery Rock 87, California (PA) 81 | Box score |
| 02/19/22 | Slippery Rock, PA | Slippery Rock 68, Gannon 63 | Box score |
| 02/16/22 | Erie, PA | Slippery Rock 71, Gannon 58 | Box score |
| 02/14/22 | Slippery Rock, PA | Slippery Rock 87, Clarion 65 | Box score |
| 02/12/22 | Greensburg, PA | Slippery Rock 80, Seton Hill 67 | Box score |
| 02/09/22 | Johnstown, PA | Pitt.-Johnstown 84, Slippery Rock 81 | Box score |
| 02/07/22 | Indiana, Pa. (Kovalchick Complex) | Indiana (PA) 72, Slippery Rock 61 | Box score |
| 02/05/22 | Slippery Rock, PA | Indiana (PA) 70, Slippery Rock 65 | Box score |
| 02/02/22 | Clarion, PA | Clarion 85, Slippery Rock 78 | Box score |
| 01/31/22 | Edinboro, PA | Slippery Rock 87, Edinboro 84 | Box score |
| 01/29/22 | Slippery Rock, PA | Cal U (PA) 92, Slippery Rock 83 | Box score |
| 01/26/22 | Millersville, PA | Millersville 77, Slippery Rock 69 | Box score |
| 01/24/22 | Slippery Rock, PA | Mercyhurst 73, Slippery Rock 66 | Box score |
| 01/15/22 | Slippery Rock, PA | Slippery Rock 70, Seton Hill 61 | Box score |
| 01/05/22 | Slippery Rock, PA | Pitt.-Johnstown 91, Slippery Rock 87 | Box score |
| 12/19/21 | Slippery Rock, PA | Slippery Rock 86, West Chester 81 | Box score |
| 12/18/21 | Slippery Rock, PA | Slippery Rock 85, Kutztown 73 | Box score |
| 12/14/21 | Slippery Rock, PA | Slippery Rock 76, Wheeling 71 | Box score |
| 12/09/21 | Slippery Rock, PA | Slippery Rock 110, Penn St-Gr Allegheny 64 | Box score |
| 12/04/21 | Bloomsburg, PA | Slippery Rock 83, Bloomsburg 79 | Box score |
| 12/03/21 | Mansfield, PA | Slippery Rock 82, Mansfield 67 | Box score |
| 11/27/21 | Charleston, WV | Charleston (WV) 78, Slippery Rock 72 | Box score |
| 11/20/21 | Slippery Rock, PA | Slippery Rock 81, East Stroudsburg 73 | Box score |
| 11/17/21 | Slippery Rock, PA | Slippery Rock 101, Penn St.-Fayette 52 | Box score |
| 11/13/21 | Slippery Rock, PA | Slippery Rock 81, Alderson Broaddus 71 | Box score |
| 11/12/21 | Slippery Rock, PA | Notre Dame (OH) 99, Slippery Rock 95 (OT) | Box score |